منابع مشابه
Two-pore Domain Potassium Channels in Astrocytes
Two-pore domain potassium (K2P) channels have a distinct structure and channel properties, and are involved in a background K+ current. The 15 members of the K2P channels are identified and classified into six subfamilies on the basis of their sequence similarities. The activity of the channels is dynamically regulated by various physical, chemical, and biological effectors. The channels are ex...
متن کاملTwo-pore domain K⁺ channels: evidence for TWIK-2 in blood pressure regulation.
The dynamic regulation of blood pressure relies on the ability of small arteries and arterioles to finely adjust their diameters to maintain peripheral vascular resistance and cardiovascular homeostasis. At the level of the vascular smooth muscle cell (VSMC), contraction is mediated by elevations in cytosolic Ca concentration enabled by Ca conducting channels located intracellularly or in the p...
متن کاملMolecular background of leak K+ currents: two-pore domain potassium channels.
Two-pore domain K(+) (K(2P)) channels give rise to leak (also called background) K(+) currents. The well-known role of background K(+) currents is to stabilize the negative resting membrane potential and counterbalance depolarization. However, it has become apparent in the past decade (during the detailed examination of the cloned and corresponding native K(2P) channel types) that this primary ...
متن کاملSerotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex.
The entorhinal cortex (EC) is regarded as the gateway to the hippocampus; the superficial layers (layers I-III) of the EC convey the cortical input projections to the hippocampus, whereas deep layers of the EC relay hippocampal output projections back to the superficial layers of the EC or to other cortical regions. The superficial layers of the EC receive strong serotonergic projections from t...
متن کاملExpression and localization of two-pore domain K(+) channels in bovine germ cells.
Two-pore domain K(+) (K(2P)) channels that help set the resting membrane potential of excitable and nonexcitable cells are expressed in many kinds of cells and tissues. However, the expression of K(2P) channels has not yet been reported in bovine germ cells. In this study, we demonstrate for the first time that K(2P) channels are expressed in the reproductive organs and germ cells of Korean cat...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.179390